Dr. Mohammad Sazzadul Islam

Biography of Dr. Mohammad Sazzadul Islam

Dr. Mohammad Sazzadul Islam has completed his Bachelor of Science (B.Sc.) and Master of Science (M.Sc.) from the Department of Biochemistry and Molecular Biology, University of Dhaka.

He did his Master’s thesis on the developing of jute ESTs from genomic clone library and determination of full length sequence of an important gene under the supervision of Professor Dr. Haseena Khan at Molecular Biology Lab, Department of Biochemistry and Molecular Biology, University of Dhaka.

After completion his Master’s degree , he joined as a Research Officer in Virology Laboratory at International Centre for Diarrheal Disease Research, Bangladesh (icddr, b) and he focused on the  identication and characterization of different respiratory viruses like Influenza virus, Rhinovirus, Adenovirus, Respiratory Syncytial Virus (RSV), Human Parainfluenza virus- 1, 2, & 3.

Dr. Sazzad completed his Doctoral degree from Chiba University, Japan. He conducted his research works in the Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan under the supervision of Professor Dr. Akira Nakagawara. During his Ph.D. research he focused on the function of novel gene called BCH motif-containing molecule at the carboxyl terminal region 1 (BMCC1), which was identified previously from their cDNA library project. He found E2F1, induced by DNA damage directly transactivates pro-apoptotic BMCC1 and facilitates ATM-dependent DNA damage response in p53 independent pathway. In addition, he has also examined that BMCC1 has pro-apoptotic function through association with anti-apoptotic BCL-2 and suppress AKT phosphorylation in neuroblastoma.

In his Postdoctoral research in the department of Genetic Engineering and Biotechnology, University of Dhaka, he was involved in the development of diagnostic tools to detect inborn errors of metabolism and genetic disorders (G6PD, Galactosemia, Methyl malonic academia and Thyroid dyshormonogenesis) using high-throughput metabolomic profiling in Bangladesh. In addition, he also worked as an Adjunct Assistant Scientist in the institute for developing Science & Health initiatives (ideSHi), Dhaka and analyzed multi-drug resistance mechanisms in bacterial pathogens among under-five children.

He is currently working as an Assistant Professor in the Department of Biochemistry and Molecular Biology at Jagannath University, Dhaka. 

 


Dr. Sazzad’s research interest is transcriptional regulation as well as cellular signaling pathway related to DNA damage response, genomic instability, apoptosis, cellular signaling and tumorigenesis. He is  interested to identify biomarkers for devastating cancers and thereby contribute for the ultimate benefits of worldwide cancer patients.

He has also interest in the elucidating of molecular mechanism of multi-drug resistance in Bangladesh perspective.