Dr. Moynul Hasan
Department of Pharmacy

Biography of Dr. Moynul Hasan

                                                 Short Biography                                                                                        

Dr. Moynul Hasan was born in Munshiganj Sadar under Munshiganj district on 2nd February 1985. He obtained his Bachelor of Pharmacy (B. Pharm.) and Master of Pharmacy (M. Pharm.) degree from Faculty of Pharmacy, University of Dhaka, Bangladesh. He joined in the Department of Pharmacy, Jagannath University in October, 2015 as a Lecturer. He successfully completed Ph.D. degree under Japanese Government MEXT (Monbukagakusho) scholarship from Shizuoka University, Japan in 2018 under the supervision of Professor Masahito Yamazaki. His doctoral study mainly focused on the biophysical characterization of antimicrobial peptides (AMPs)-lipid membrane interactions at a molecular level. Mentionably, He revealed the mechanism of initial stage of pore formation in lipid membrane by antimicrobial peptide magainin 2. Moreover, he established a new approach to prepare asymmetric model membrane and developed a novel method to estimate the transbilayer movement (flip-flop) of lipids in lipid membrane. He was promoted to Asistant Professor in the same Department in December 2019. 

 

                                                               Research Interest                                                                

  • Single cell biophysical study of peptide-membrane interaction   
  • Design, synthesis and characterization of peptides
  • Reconstitution of proteins such as bacterial porin or mechanosensitive ion channel in model membrane (proteo-liposomes)
  • Formulation and characterization of liposomal drug delivery system for proteins (e.g., antimicrobial peptides
  • Preparation of novel biomimetic model membranes (e.g., membrane mimetic to outer membrane or inner membrane of gram-negative bacteria)  
  • Flip-flop study of lipid molecules
  • Structure-activity relationship study of AMPs

             

                                                              Research Experiences                                                          


  • Real time observation of interaction of antimicrobial peptide with artificial lipid membrane using “the single GUV* method” (*GUV: Giant Unilameller Vesicle, diameter ≥ 10 µm).
  • Establish a new approach to prepare GUVs with asymmetric lipid composition in two monolayers.
  • Establish a new method to estimate the rate of transbilayer movement of lipids (flip-flop) in absence/presence of peptide.
  • Measurement of elastic property of GUVs or peptide-induced fractional area change in GUVs by micropipette aspiration method
  • Measurement of biophysical property (e.g., binding constant, CMC etc.) of several lyso lipids (e.g., NBD-labeled lyso PE).  
  • Design, synthesis and characterization of several mutants of antimicrobial peptide magainin 2 to investigate structure-activity relationship of this peptide.
  • Labeling of peptide by several fluorescent molecules (e.g., carboxy fluoerscein)
  • Formulation and evaluation of sustained release and floating dosage forms.
  • RP-HPLC method development for peptide purification.
 

 

 

 

 

 

 

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